Vanadium Complexes with Thioanilide Derivatives of Amino Acids: Inhibition of Human Phosphatases and Specificity in Various Cell Models of Metabolic Disturbances

• Main Authors: Grzegorz Kazek (Author), Monika Głuch-Lutwin (Author), Barbara Mordyl (Author), Elżbieta Menaszek (Author), Monika Kubacka (Author), Anna Jurowska (Author), Dariusz Cież (Author), Bartosz Trzewik (Author), Janusz Szklarzewicz (Author), Monika A. Papież (Author)
• Format: Book
• Published: MDPI AG, 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In the text, the synthesis and characteristics of the novel ONS-type vanadium (V) complexes with thioanilide derivatives of amino acids are described. They showed the inhibition of human protein tyrosine phosphatases (PTP1B, LAR, SHP1, and SHP2) in the submicromolar range, as well as the inhibition...