Polymeric nanoparticles developed by vitamin E-modified aliphatic polycarbonate polymer to promote oral absorption of oleanolic acid

• Main Authors: Wenjuan Zhang (Author), Chufan Liang (Author), Hao Liu (Author), Zhenbao Li (Author), Rui Chen (Author), Mei Zhou (Author), Dan Li (Author), Qing Ye (Author), Cong Luo (Author), Jin Sun (Author)
• Format: Book
• Published: Elsevier, 2017-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oleanolic acid (OA) exhibited good pharmacological activities in the clinical treatment of hypoglycemia, immune regulation, acute jaundice and chronic toxic hepatitis. However, the oral delivery of OA is greatly limited by its inferior water solubility and poor intestinal mucosa permeability. Herein...