Iron Chelation in Murine Models of Systemic Inflammation Induced by Gram-Positive and Gram-Negative Toxins

• Главные авторы: Danielle Fokam (Автор), Kayle Dickson (Автор), Kiyana Kamali (Автор), Bruce Holbein (Автор), Patricia Colp (Автор), Ashley Stueck (Автор), Juan Zhou (Автор), Christian Lehmann (Автор)
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• Опубликовано: MDPI AG, 2020-05-01T00:00:00Z.
• Предметы: article
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Iron is an essential element for various physiological processes, but its levels must remain tightly regulated to avoid cellular damage. Similarly, iron plays a dual role in systemic inflammation, such as with sepsis. Leukocytes utilize iron to produce reactive oxygen species (ROS) to kill bacteria,...