Iron Chelation in Murine Models of Systemic Inflammation Induced by Gram-Positive and Gram-Negative Toxins

• Egile Nagusiak: Danielle Fokam (Egilea), Kayle Dickson (Egilea), Kiyana Kamali (Egilea), Bruce Holbein (Egilea), Patricia Colp (Egilea), Ashley Stueck (Egilea), Juan Zhou (Egilea), Christian Lehmann (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2020-05-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Iron is an essential element for various physiological processes, but its levels must remain tightly regulated to avoid cellular damage. Similarly, iron plays a dual role in systemic inflammation, such as with sepsis. Leukocytes utilize iron to produce reactive oxygen species (ROS) to kill bacteria,...