High expression of uracil DNA glycosylase determines C to T substitution in human pluripotent stem cells

• Main Authors: Ju-Chan Park (Author), Hyeon-Ki Jang (Author), Jumee Kim (Author), Jun Hee Han (Author), Youngri Jung (Author), Keuntae Kim (Author), Sangsu Bae (Author), Hyuk-Jin Cha (Author)
• Format: Book
• Published: Elsevier, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Precise genome editing of human pluripotent stem cells (hPSCs) is crucial not only for basic science but also for biomedical applications such as ex vivo stem cell therapy and genetic disease modeling. However, hPSCs have unique cellular properties compared to somatic cells. For instance, hPSCs are...