Multi-omics integration identifies cell-state-specific repression by PBRM1-PIAS1 cooperation

• Main Authors: Patric J. Ho (Author), Junghun Kweon (Author), Laura A. Blumensaadt (Author), Amy E. Neely (Author), Elizabeth Kalika (Author), Daniel B. Leon (Author), Sanghyon Oh (Author), Cooper W.P. Stringer (Author), Sarah M. Lloyd (Author), Ziyou Ren (Author), Xiaomin Bao (Author)
• Format: Book
• Published: Elsevier, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary: PBRM1 is frequently mutated in cancers of epithelial origin. How PBRM1 regulates normal epithelial homeostasis, prior to cancer initiation, remains unclear. Here, we show that PBRM1's gene regulatory roles differ drastically between cell states, leveraging human skin epithelium (epider...