Butterfly Effect in Cytarabine: Combined NMR-NQR Experiment, Solid-State Computational Modeling, Quantitative Structure-Property Relationships and Molecular Docking Study

• Autors principals: Jolanta Natalia Latosińska (Autor), Magdalena Latosińska (Autor), Janez Seliger (Autor), Veselko Žagar (Autor), Tomaž Apih (Autor)
• Format: Llibre
• Publicat: MDPI AG, 2024-03-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Cytarabine (Ara-C) is a synthetic isomer of cytidine that differs from cytidine and deoxycytidine only in the sugar. The use of arabinose instead of deoxyribose hinders the formation of phosphodiester linkages between pentoses, preventing the DNA chain from elongation and interrupting the DNA synthe...