Peripheral injury of pelvic visceral sensory nerves alters GFRa (GDNF family receptor alpha) localization in sensory and autonomic pathways of the sacral spinal cord

• Main Authors: Shelley Lynne Forrest (Author), Sophie Clementine Payne (Author), Janet R Keast (Author), Peregrine B Osborne (Author)
• Format: Book
• Published: Frontiers Media S.A., 2015-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

GDNF (glial cell line-derived neurotrophic factor), neurturin and artemin use their co-receptors (GFRα1, GFRα2 and GFRα3, respectively) and the tyrosine kinase Ret for downstream signalling. In rodent dorsal root ganglia (DRG) most of the unmyelinated and some myelinated sensory afferents express at...