Experimental Study of Almonertinib Crossing the Blood-Brain Barrier in EGFR-Mutant NSCLC Brain Metastasis and Spinal Cord Metastasis Models

• Main Authors: Yuhan Zhang (Author), Yaoshuai Zhang (Author), Wenwen Niu (Author), Xianming Ge (Author), Fuhao Huang (Author), Jinlong Pang (Author), Xian Li (Author), Yu Wang (Author), Wei Gao (Author), Fangtian Fan (Author), Shanshan Li (Author), Hao Liu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Roughly one third of non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI)-sensitive mutated (EGFRm) tumors experience disease progression through central nervous system (CNS) metastases during treatment. Although EGFR-TKIs have been r...