Prevalence of Mutations in the <i>pfcoronin</i> Gene and Association with Ex Vivo Susceptibility to Common Quinoline Drugs against <i>Plasmodium falciparum</i>

• Main Authors: Océane Delandre (Author), Mathieu Gendrot (Author), Isabelle Fonta (Author), Joel Mosnier (Author), Nicolas Benoit (Author), Rémy Amalvict (Author), Nicolas Gomez (Author), Marylin Madamet (Author), Bruno Pradines (Author)
• Format: Book
• Published: MDPI AG, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Artemisinin-based combination therapy (ACT) was recommended to treat uncomplicated falciparum malaria. Unlike the situation in Asia where resistance to ACT has been reported, artemisinin resistance has not yet emerged in Africa. However, some rare failures with ACT or patients continuing...