Exosomes derived from 3D-cultured MSCs improve therapeutic effects in periodontitis and experimental colitis and restore the Th17 cell/Treg balance in inflamed periodontium

• Main Authors: Yong Zhang (Author), Jiayao Chen (Author), Haijun Fu (Author), Shuhong Kuang (Author), Feng He (Author), Min Zhang (Author), Zongshan Shen (Author), Wei Qin (Author), Zhengmei Lin (Author), Shuheng Huang (Author)
• Format: Book
• Published: Nature Publishing Group, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Although mesenchymal stem cell-derived exosomes (MSC-exos) have been shown to have therapeutic effects in experimental periodontitis, their drawbacks, such as low yield and limited efficacy, have hampered their clinical application. These drawbacks can be largely reduced by replacing the tr...