PIK3CA mutation in endometriotic epithelial cells promotes viperin-dependent inflammatory response to insulin

• Main Authors: Mike R. Wilson (Author), Shannon Harkins (Author), Jake J. Reske (Author), Rebecca A. Siwicki (Author), Marie Adams (Author), Victoria L. Bae-Jump (Author), Jose M. Teixeira (Author), Ronald L. Chandler (Author)
• Format: Book
• Published: BMC, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Endometrial epithelia are known to harbor cancer driver mutations in the absence of any pathologies, including mutations in PIK3CA. Insulin plays an important role in regulating uterine metabolism during pregnancy, and hyperinsulinemia is associated with conditions impacting fertility. Hype...