DJ-1 Deficiency Protects against Sepsis-Induced Myocardial Depression

• Главные авторы: James N. Tsoporis (Автор), Hajera Amatullah (Автор), Sahil Gupta (Автор), Shehla Izhar (Автор), Amin M. Ektesabi (Автор), Chirag M. Vaswani (Автор), Jean-Francois Desjardins (Автор), Golam Kabir (Автор), Ana Paula Teixera Monteiro (Автор), Amir K. Varkouhi (Автор), Nikolaos Kavantzas (Автор), Vasileios Salpeas (Автор), Ioannis Rizos (Автор), John C. Marshall (Автор), Thomas G. Parker (Автор), Howard Leong-Poi (Автор), Claudia C. dos Santos (Автор)
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• Опубликовано: MDPI AG, 2023-02-01T00:00:00Z.
• Предметы: article
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Oxidative stress is considered one of the early underlying contributors of sepsis-induced myocardial depression. DJ-1, also known as PARK7, has a well-established role as an antioxidant. We have previously shown, in a clinically relevant model of polymicrobial sepsis, DJ-1 deficiency improved surviv...