DJ-1 Deficiency Protects against Sepsis-Induced Myocardial Depression

• Main Authors: James N. Tsoporis (Author), Hajera Amatullah (Author), Sahil Gupta (Author), Shehla Izhar (Author), Amin M. Ektesabi (Author), Chirag M. Vaswani (Author), Jean-Francois Desjardins (Author), Golam Kabir (Author), Ana Paula Teixera Monteiro (Author), Amir K. Varkouhi (Author), Nikolaos Kavantzas (Author), Vasileios Salpeas (Author), Ioannis Rizos (Author), John C. Marshall (Author), Thomas G. Parker (Author), Howard Leong-Poi (Author), Claudia C. dos Santos (Author)
• Format: Book
• Published: MDPI AG, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oxidative stress is considered one of the early underlying contributors of sepsis-induced myocardial depression. DJ-1, also known as PARK7, has a well-established role as an antioxidant. We have previously shown, in a clinically relevant model of polymicrobial sepsis, DJ-1 deficiency improved surviv...