SHP2 inhibition improves celastrol-induced growth suppression of colorectal cancer

• Main Authors: Linxi Zhang (Author), Xuefei Hu (Author), Qingying Meng (Author), Ye Li (Author), Hao Shen (Author), Yating Fu (Author), Fan Zhang (Author), Jiahui Chen (Author), Wei Zhang (Author), Wenjun Chang (Author), Yamin Pan (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study aimed to explore novel targets for celastrol sensitization in colorectal cancer (CRC) based on differentially regulated signals in response to high- or low-dose celastrol. Targeting signals were investigated using Western blotting or phosphorylated receptor tyrosine kinase (RTK) arrays. C...