The effect of itraconazole, a strong CYP3A4 inhibitor, on the pharmacokinetics of the first‐in‐class ACKR3/CXCR7 antagonist, ACT‐1004‐1239

The effect of itraconazole, a strong CYP3A4 inhibitor, on the pharmacokinetics of the first‐in‐class ACKR3/CXCR7 antagonist, ACT‐1004‐1239

Abstract Cytochrome P450 (CYP) 3A4 is an enzyme involved in the metabolism of many drugs that are currently on the market and is therefore a key player in drug-drug interactions (DDIs). ACT‐1004‐1239 is a potent and selective, first‐in‐class ACKR3/CXRC7 antagonist being developed as a treatment for...

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Main Authors: Christine Huynh (Author), Jasper Dingemanse (Author), Henriette E. Meyer zu Schwabedissen (Author), Marlene Fonseca (Author), Patricia N. Sidharta (Author)
Format: Book
Published: Wiley, 2024-07-01T00:00:00Z.
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