The Antimalarial Chloroquine Suppresses LPS-Induced NLRP3 Inflammasome Activation and Confers Protection against Murine Endotoxic Shock

Activation of the NLRP3 inflammasome, which catalyzes maturation of proinflammatory cytokines like IL-1β and IL-18, is implicated and essentially involved in many kinds of inflammatory disorders. Chloroquine (CQ) is a traditional antimalarial drug and also possesses an anti-inflammatory property. In...

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Main Authors: Xiaoli Chen (Author), Ning Wang (Author), Yuanfeng Zhu (Author), Yongling Lu (Author), Xin Liu (Author), Jiang Zheng (Author)
Format: Book
Published: Hindawi Limited, 2017-01-01T00:00:00Z.
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