The Antimalarial Chloroquine Suppresses LPS-Induced NLRP3 Inflammasome Activation and Confers Protection against Murine Endotoxic Shock

• Asıl Yazarlar: Xiaoli Chen (Yazar), Ning Wang (Yazar), Yuanfeng Zhu (Yazar), Yongling Lu (Yazar), Xin Liu (Yazar), Jiang Zheng (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Hindawi Limited, 2017-01-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Activation of the NLRP3 inflammasome, which catalyzes maturation of proinflammatory cytokines like IL-1β and IL-18, is implicated and essentially involved in many kinds of inflammatory disorders. Chloroquine (CQ) is a traditional antimalarial drug and also possesses an anti-inflammatory property. In...