Computational Design and Optimization of Peptide Inhibitors for SIRT2

• Main Authors: Heba A. Alkhatabi (Author), Fatmah M. A. Naemi (Author), Reem Alsolami (Author), Hisham N. Alatyb (Author)
• Format: Book
• Published: MDPI AG, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sirtuin 2 (SIRT2), an NAD+-dependent deacetylase, is crucial for regulating vital physiological processes, including aging, DNA repair, and cell cycle progression. Its abnormal activity is linked to diseases such as Parkinson's disease, cancer, and metabolic disorders, making it a potential tar...