Oligo-PROTAC strategy for cell-selective and targeted degradation of activated STAT3

• Main Authors: Jeremy Hall (Author), Zhuoran Zhang (Author), Supriyo Bhattacharya (Author), Dongfang Wang (Author), Marice Alcantara (Author), Yong Liang (Author), Piotr Swiderski (Author), Stephen Forman (Author), Larry Kwak (Author), Nagarajan Vaidehi (Author), Marcin Kortylewski (Author)
• Format: Book
• Published: Elsevier, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Decoy oligodeoxynucleotides (ODNs) allow targeting undruggable transcription factors, such as STAT3, but their limited potency and lack of delivery methods hampered translation. To overcome these challenges, we conjugated a STAT3-specific decoy to thalidomide, a ligand to cereblon in E3 ubiquitin li...