Integrated analysis of DNA methylation and gene expression reveals specific signaling pathways associated with platinum resistance in ovarian cancer

• Main Authors: Chung Jae (Author), Jeong Mikyoung (Author), Montgomery John S (Author), Balch Curt (Author), Li Meng (Author), Yan Pearlly (Author), Huang Tim HM (Author), Kim Sun (Author), Nephew Kenneth P (Author)
• Format: Book
• Published: BMC, 2009-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Cisplatin and carboplatin are the primary first-line therapies for the treatment of ovarian cancer. However, resistance to these platinum-based drugs occurs in the large majority of initially responsive tumors, resulting in fully che...