ERBB2‐amplified lobular breast carcinoma exhibits concomitant CDK12 co‐amplification associated with poor prognostic features

• मुख्य लेखकों: Miriam Forster‐Sack (लेखक), Martin Zoche (लेखक), Bernhard Pestalozzi (लेखक), Isabell Witzel (लेखक), Esther Irene Schwarz (लेखक), Joel Julien Herzig (लेखक), Hisham Fansa (लेखक), Christoph Tausch (लेखक), Jeff Ross (लेखक), Holger Moch (लेखक), Zsuzsanna Varga (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Wiley, 2024-03-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract Most invasive lobular breast carcinomas (ILBCs) are luminal‐type carcinomas with an HER2‐negative phenotype (ERBB2 or HER2 un‐amplified) and CDH1 mutations. Rare variants include ERBB2‐amplified subtypes associated with an unfavorable prognosis and less response to anti‐HER2 targeted therap...