ERBB2‐amplified lobular breast carcinoma exhibits concomitant CDK12 co‐amplification associated with poor prognostic features

• Main Authors: Miriam Forster‐Sack (Author), Martin Zoche (Author), Bernhard Pestalozzi (Author), Isabell Witzel (Author), Esther Irene Schwarz (Author), Joel Julien Herzig (Author), Hisham Fansa (Author), Christoph Tausch (Author), Jeff Ross (Author), Holger Moch (Author), Zsuzsanna Varga (Author)
• Format: Book
• Published: Wiley, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Most invasive lobular breast carcinomas (ILBCs) are luminal‐type carcinomas with an HER2‐negative phenotype (ERBB2 or HER2 un‐amplified) and CDH1 mutations. Rare variants include ERBB2‐amplified subtypes associated with an unfavorable prognosis and less response to anti‐HER2 targeted therap...