Contribution of the co-chaperone FKBP51 in the ventromedial hypothalamus to metabolic homeostasis in male and female mice

• Main Authors: Lea M. Brix (Author), Irmak Toksöz (Author), London Aman (Author), Veronika Kovarova (Author), Margherita Springer (Author), Joeri Bordes (Author), Lotte van Doeselaar (Author), Clara Engelhardt (Author), Alexander S. Häusl (Author), Sowmya Narayan (Author), Vera Sterlemann (Author), Huanqing Yang (Author), Jan M. Deussing (Author), Mathias V. Schmidt (Author)
• Format: Book
• Published: Elsevier, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Steroidogenic factor 1 (SF1) expressing neurons in the ventromedial hypothalamus (VMH) have been directly implicated in whole-body metabolism and in the onset of obesity. The co-chaperone FKBP51 is abundantly expressed in the VMH and was recently linked to type 2 diabetes, insulin resista...