Sea-anemone toxin ATX-II elicits A-fiber-dependent pain and enhances resurgent and persistent sodium currents in large sensory neurons

• Main Authors: Klinger Alexandra B (Author), Eberhardt Mirjam (Author), Link Andrea S (Author), Namer Barbara (Author), Kutsche Lisa K (Author), Schuy E (Author), Sittl Ruth (Author), Hoffmann Tali (Author), Alzheimer Christian (Author), Huth Tobias (Author), Carr Richard W (Author), Lampert Angelika (Author)
• Format: Book
• Published: SAGE Publishing, 2012-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Gain-of-function mutations of the nociceptive voltage-gated sodium channel Nav1.7 lead to inherited pain syndromes, such as paroxysmal extreme pain disorder (PEPD). One characteristic of these mutations is slowed fast-inactivation ki...