Isobutyrylcarnitine as a Biomarker of OCT1 Activity and Interspecies Differences in its Membrane Transport

• Autors principals: Ole Jensen (Autor), Johannes Matthaei (Autor), Henry G. Klemp (Autor), Marleen J. Meyer (Autor), Jürgen Brockmöller (Autor), Mladen V. Tzvetkov (Autor)
• Format: Llibre
• Publicat: Frontiers Media S.A., 2021-05-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Genome-wide association studies have identified an association between isobutyrylcarnitine (IBC) and organic cation transporter 1 (OCT1) genotypes. Higher IBC blood concentrations in humans with active OCT1 genotypes and experimental studies with mouse OCT1 suggested an OCT1-mediated efflux of IBC....