HMGA1 augments palbociclib efficacy via PI3K/mTOR signaling in intrahepatic cholangiocarcinoma

• मुख्य लेखकों: Zhipeng Li (लेखक), Huaxin Zhou (लेखक), Zhijia Xia (लेखक), Tong Xia (लेखक), Gang Du (लेखक), Strohmer Dorothee Franziska (लेखक), Xiaoming Li (लेखक), Xiangyu Zhai (लेखक), Bin Jin (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: BMC, 2023-03-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract Background Intrahepatic cholangiocarcinoma (iCCA) is a highly aggressive cancer that is challenging to diagnose at an early stage. Despite recent advances in combination chemotherapy, drug resistance limits the therapeutic value of this regimen. iCCA reportedly harbors high HMGA1 expression...