HMGA1 augments palbociclib efficacy via PI3K/mTOR signaling in intrahepatic cholangiocarcinoma

• Main Authors: Zhipeng Li (Author), Huaxin Zhou (Author), Zhijia Xia (Author), Tong Xia (Author), Gang Du (Author), Strohmer Dorothee Franziska (Author), Xiaoming Li (Author), Xiangyu Zhai (Author), Bin Jin (Author)
• Formato: Livro
• Publicado em: BMC, 2023-03-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Abstract Background Intrahepatic cholangiocarcinoma (iCCA) is a highly aggressive cancer that is challenging to diagnose at an early stage. Despite recent advances in combination chemotherapy, drug resistance limits the therapeutic value of this regimen. iCCA reportedly harbors high HMGA1 expression...