Distribution in Rat Blood and Brain of TDMQ20, a Copper Chelator Designed as a Drug-Candidate for Alzheimer's Disease

• Päätekijät: Lan Huang (Tekijä), Yaoxun Zeng (Tekijä), Yongliang Li (Tekijä), Yingshan Zhu (Tekijä), Yan He (Tekijä), Yan Liu (Tekijä), Anne Robert (Tekijä), Bernard Meunier (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: MDPI AG, 2022-12-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

(1) Background: TDMQ20 is a specific regulator of copper homeostasis in the brain, able to inhibit cognitive impairment in the early stages of Alzheimer's disease (AD) in mouse models of AD. To promote the further development of this drug-candidate, preliminary data on the pharmacokinetics of T...