Effect of Formulation Factors and Oxygen Levels on the Stability of Aqueous Injectable Solution Containing Pemetrexed

• Main Authors: Dong Han Won (Author), Heejun Park (Author), Eun-Sol Ha (Author), Yong Min Kim (Author), Hyung Don Hwang (Author), Sun Woo Jang (Author), Min-Soo Kim (Author)
• Format: Book
• Published: MDPI AG, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The aim of this study was to investigate the effects of various parameters at each control strategy in drug product degradation on the stability of pemetrexed in injectable aqueous solution. A forced degradation study confirmed that oxidation is the main mechanism responsible for the degradation of...