Effects of endotoxin exposure on childhood asthma risk are modified by a genetic polymorphism in ACAA1

• Main Authors: Sordillo Joanne E (Author), Sharma Sunita (Author), Poon Audrey (Author), Lasky-Su Jessica (Author), Belanger Kathleen (Author), Milton Donald K (Author), Bracken Michael B (Author), Triche Elizabeth W (Author), Leaderer Brian P (Author), Gold Diane R (Author), Litonjua Augusto A (Author)
• Format: Book
• Published: BMC, 2011-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Polymorphisms in the endotoxin-mediated TLR4 pathway genes have been associated with asthma and atopy. We aimed to examine how genetic polymorphisms in innate immunity pathways interact with endotoxin to influence asthma risk in chil...