Yeast-expressed recombinant As16 protects mice against Ascaris suum infection through induction of a Th2-skewed immune response.

• Main Authors: Junfei Wei (Author), Leroy Versteeg (Author), Zhuyun Liu (Author), Brian Keegan (Author), Ana Clara Gazzinelli-Guimarães (Author), Ricardo T Fujiwara (Author), Neima Briggs (Author), Kathryn M Jones (Author), Ulrich Strych (Author), Coreen M Beaumier (Author), Maria Elena Bottazzi (Author), Peter J Hotez (Author), Bin Zhan (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Ascariasis remains the most common helminth infection in humans. As an alternative or complementary approach to global deworming, a pan-anthelminthic vaccine is under development targeting Ascaris, hookworm, and Trichuris infections. As16 and As14 have previously been described as two gen...