Hepatotoxicity of AKR1C3 Inhibitor BAY1128688: Findings from an Early Terminated Phase IIa Trial for the Treatment of Endometriosis

• Main Authors: Jan Hilpert (Author), Esther Groettrup-Wolfers (Author), Hristiyan Kosturski (Author), Laura Bennett (Author), Catriona L. K. Barnes (Author), Kerstin Gude (Author), Isabella Gashaw (Author), Stefanie Reif (Author), Thomas Steger-Hartmann (Author), Christian Scheerans (Author), Alexander Solms (Author), Antje Rottmann (Author), Guangping Mao (Author), Charles Chapron (Author)
• Format: Book
• Published: Adis, Springer Healthcare, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Introduction BAY1128688 is a selective inhibitor of aldo-keto reductase family 1 member C3 (AKR1C3), an enzyme implicated in the pathology of endometriosis and other disorders. In vivo animal studies suggested a potential therapeutic application of BAY1128688 in treating endometriosis. Earl...