Epigenetically modulated miR-1224 suppresses the proliferation of HCC through CREB-mediated activation of YAP signaling pathway

• Main Authors: Shikun Yang (Author), Wei Jiang (Author), Wenjie Yang (Author), Chao Yang (Author), Xinchen Yang (Author), Keyan Chen (Author), Yuanchang Hu (Author), Gefenqiang Shen (Author), Ling Lu (Author), Feng Cheng (Author), Feng Zhang (Author), Jianhua Rao (Author), Xuehao Wang (Author)
• Format: Book
• Published: Elsevier, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mounting evidence has demonstrated that microRNA-1224 (miR-1224) is commonly downregulated and serves as a tumor suppressor in multiple malignancies. However, the role and mechanisms responsible for miR-1224 in hepatocellular carcinoma (HCC) remain unclear. In this study, we found that the expressio...