Evaluation of the Drug-Induced Liver Injury Potential of Saxagliptin through Reactive Metabolite Identification in Rats

• Main Authors: Ki-Young Kim (Author), Yeo-Jin Jeong (Author), So-Young Park (Author), Eun-Ji Park (Author), Ji-Hyeon Jeon (Author), Im-Sook Song (Author), Kwang-Hyeon Liu (Author)
• Format: Book
• Published: MDPI AG, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A liver injury was recently reported for saxagliptin, which is a dipeptidyl peptidase-4 (DPP-4) inhibitor. However, the underlying mechanisms of saxagliptin-induced liver injury remain unknown. This study aimed to evaluate whether saxagliptin, a potent and selective DPP-4 inhibitor that is globally...