Factors and Mechanisms for Pharmacokinetic Differences between Pediatric Population and Adults

• Main Authors: Jose T. Ramos (Author), Marta Arteta (Author), Pilar Tejada (Author), Alfredo Hernandez (Author), Raul Perez (Author), Eva Fernandez (Author)
• Format: Book
• Published: MDPI AG, 2011-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Many physiologic differences between children and adults may result in age-related changes in pharmacokinetics and pharmacodynamics. Factors such as gastric pH and emptying time, intestinal transit time, immaturity of secretion and activity of bile and pancreatic fluid among other factors determine...