Design, synthesis and antitumour activity evaluation of novel dolutegravir derivatives

• Main Authors: Xi-Xi Hou (Author), Long-Fei Mao (Author), Yajie Guo (Author), Chaoxuan Lou (Author), Lan Wang (Author), Rui-Fang Li (Author), Huili Wang (Author), San-Qiang Li (Author), Jian-Xue Yang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Based on the modification of the structure of dolutegravir, we introduced 1,2,3-triazole moieties with different substituted groups and obtained a lot of novel dolutegravir derivatives. The activity of A549 cells treated with the derivatives was examined, and most compounds showed good inhibitory ef...