Design, synthesis and antitumour activity evaluation of novel dolutegravir derivatives

• Hoofdauteurs: Xi-Xi Hou (Auteur), Long-Fei Mao (Auteur), Yajie Guo (Auteur), Chaoxuan Lou (Auteur), Lan Wang (Auteur), Rui-Fang Li (Auteur), Huili Wang (Auteur), San-Qiang Li (Auteur), Jian-Xue Yang (Auteur)
• Formaat: Boek
• Gepubliceerd in: Frontiers Media S.A., 2023-08-01T00:00:00Z.
• Onderwerpen: article
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Based on the modification of the structure of dolutegravir, we introduced 1,2,3-triazole moieties with different substituted groups and obtained a lot of novel dolutegravir derivatives. The activity of A549 cells treated with the derivatives was examined, and most compounds showed good inhibitory ef...