PDE9 Inhibitor PF-04447943 Attenuates DSS-Induced Colitis by Suppressing Oxidative Stress, Inflammation, and Regulating T-Cell Polarization

• Main Authors: Mohammad Nasiruddin Rana (Author), Jie Lu (Author), Enfu Xue (Author), Jingjing Ruan (Author), Yuting Liu (Author), Lejun Zhang (Author), Rana Dhar (Author), Yajun Li (Author), Zhengqiang Hu (Author), Jie Zhou (Author), Wangqian Ma (Author), Huifang Tang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ulcerative colitis (UC) is a form of inflammatory bowel disease, which manifests as irritation or swelling and sores in the large intestine in a relapsing and remitting manner. In a dextran sulfate sodium sulfate (DSS)-induced UC model in female mice, we found that the levels of cyclic guanosine mon...