Bone-Seeking Matrix Metalloproteinase Inhibitors for the Treatment of Skeletal Malignancy

• Main Authors: Antonio Laghezza (Author), Luca Piemontese (Author), Leonardo Brunetti (Author), Alessia Caradonna (Author), Mariangela Agamennone (Author), Antonella Di Pizio (Author), Giorgio Pochetti (Author), Roberta Montanari (Author), Davide Capelli (Author), Marilena Tauro (Author), Fulvio Loiodice (Author), Paolo Tortorella (Author)
• Format: Book
• Published: MDPI AG, 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Matrix metalloproteinases (MMPs) are a family of enzymes involved at different stages of cancer progression and metastasis. We previously identified a novel class of bisphosphonic inhibitors, selective for MMPs crucial for bone remodeling, such as MMP-2. Due to the increasing relevance of specific M...