Discovery and characterization of prolactin neutralizing monoclonal antibodies for the treatment of female-prevalent pain disorders

• Главные авторы: Stephanie Maciuba (Автор), Gregory D. Bowden (Автор), Harrison J. Stratton (Автор), Kazimierz Wisniewski (Автор), Claudio D. Schteingart (Автор), Juan C. Almagro (Автор), Philippe Valadon (Автор), Joshua Lowitz (Автор), Scott M. Glaser (Автор), Grace Lee (Автор), Mahdi Dolatyari (Автор), Edita Navratilova (Автор), Frank Porreca (Автор), Pierre J.M. Rivière (Автор)
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• Опубликовано: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Предметы: article
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ABSTRACTProlactin (PRL) has recently been demonstrated to elicit female-selective nociceptor sensitization and increase pain-like behaviors in female animals. Here we report the discovery and characterization of first-in-class, humanized PRL neutralizing monoclonal antibodies (PRL mAbs). We obtained...