Discovery and characterization of prolactin neutralizing monoclonal antibodies for the treatment of female-prevalent pain disorders

• Main Authors: Stephanie Maciuba (Author), Gregory D. Bowden (Author), Harrison J. Stratton (Author), Kazimierz Wisniewski (Author), Claudio D. Schteingart (Author), Juan C. Almagro (Author), Philippe Valadon (Author), Joshua Lowitz (Author), Scott M. Glaser (Author), Grace Lee (Author), Mahdi Dolatyari (Author), Edita Navratilova (Author), Frank Porreca (Author), Pierre J.M. Rivière (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTProlactin (PRL) has recently been demonstrated to elicit female-selective nociceptor sensitization and increase pain-like behaviors in female animals. Here we report the discovery and characterization of first-in-class, humanized PRL neutralizing monoclonal antibodies (PRL mAbs). We obtained...