Sulfation of chondroitin and bile acids converges to antagonize Wnt/β-catenin signaling and inhibit APC deficiency-induced gut tumorigenesis

• Main Authors: Pengfei Xu (Author), Yue Xi (Author), Jong-Won Kim (Author), Junjie Zhu (Author), Min Zhang (Author), Meishu Xu (Author), Songrong Ren (Author), Da Yang (Author), Xiaochao Ma (Author), Wen Xie (Author)
• Format: Book
• Published: Elsevier, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sulfation is a crucial and prevalent conjugation reaction involved in cellular processes and mammalian physiology. 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) synthase 2 (PAPSS2) is the primary enzyme to generate the universal sulfonate donor PAPS. The involvement of PAPSS2-mediated sulfa...