Association of CYP2D6 polymorphisms and extrapyramidal symptoms in schizophrenia patients receiving risperidone: a retrospective study

• Main Authors: Takahiro Ito (Author), Kazuhiro Yamamoto (Author), Fuminori Ohsawa (Author), Ikuo Otsuka (Author), Akitoyo Hishimoto (Author), Ichiro Sora (Author), Midori Hirai (Author), Ikuko Yano (Author)
• Format: Book
• Published: BMC, 2018-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Risperidone is mainly metabolized by cytochrome P450 (CYP) 2D6 in the liver. The gene encoding CYP2D6 is highly polymorphic. The average steady-state plasma concentration of risperidone active moiety is higher in the CYP2D6 intermediate metabolizers (IMs) compared with that in th...