Gossypol Inhibits Non-small Cell Lung Cancer Cells Proliferation by Targeting EGFRL858R/T790M

• Main Authors: Yuwei Wang (Author), Huanling Lai (Author), Xingxing Fan (Author), Lianxiang Luo (Author), Fugang Duan (Author), Zebo Jiang (Author), Qianqian Wang (Author), Elaine Lai Han Leung (Author), Liang Liu (Author), Xiaojun Yao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Overexpression of epidermal growth factor receptor (EGFR) has been reported to be implicated in the pathogenesis of non-small cell lung cancer (NSCLC). Several EGFR inhibitors have been used in clinical treatment of NSCLC, but the emergence of EGFRL858R/T790M resistant mutation has reduc...