Characterization of neutralizing chimeric heavy-chain antibodies against tetanus toxin

• Main Authors: Kexuan Cheng (Author), Jiansheng Lu (Author), Jiazheng Guo (Author), Rong Wang (Author), Lei Chen (Author), Xi Wang (Author), Yujia Jiang (Author), Yating Li (Author), Changyan Xu (Author), Qinglin Kang (Author), Gulisaina Qiaerxie (Author), Peng Du (Author), Chen Gao (Author), Yunzhou Yu (Author), Zhixin Yang (Author), Wei Wang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tetanus toxin (TeNT) is one of the most toxic proteins. Neutralizing antibodies against TeNT are effective in prevention and treatment. In this study, 14 anti-tetanus nanobodies were obtained from a phage display nanobody library by immunizing a camel with the C-terminal receptor-binding domain of T...