A simplified herbal decoction attenuates myocardial infarction by regulating macrophage metabolic reprogramming and phenotypic differentiation via modulation of the HIF-1α/PDK1 axis

• Main Authors: Zhi-jun Lin (Author), Xin Dong (Author), Huan He (Author), Jia-lin Jiang (Author), Zhuo-ji Guan (Author), Xuan Li (Author), Lu Lu (Author), Huan Li (Author), Yu-sheng Huang (Author), Shao-xiang Xian (Author), Zhong-qi Yang (Author), Zi-xin Chen (Author), Hong-cheng Fang (Author), Ling-jun Wang (Author)
• Format: Book
• Published: BMC, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Myocardial infarction (MI) poses a global public health challenge, often associated with elevated mortality rates and a grim prognosis. A crucial aspect of the inflammatory injury and healing process post-MI involves the dynamic differentiation of macrophages. A promising strateg...