Inhibition of K63 ubiquitination by G-Protein pathway suppressor 2 (GPS2) regulates mitochondria-associated translation

• Main Authors: Yuan Gao (Author), Julian Kwan (Author), Joseph Orofino (Author), Giulia Burrone (Author), Sahana Mitra (Author), Ting-Yu Fan (Author), Justin English (Author), Ryan Hekman (Author), Andrew Emili (Author), Shawn M. Lyons (Author), Maria Dafne Cardamone (Author), Valentina Perissi (Author)
• Format: Book
• Published: Elsevier, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

G-Protein Pathway Suppressor 2 (GPS2) is an inhibitor of non-proteolytic K63 ubiquitination mediated by the E2 ubiquitin-conjugating enzyme Ubc13. Previous studies have associated GPS2-mediated restriction of ubiquitination with the regulation of insulin signaling, inflammatory responses and mitocho...