Lovastatin-Induced Mitochondrial Oxidative Stress Leads to the Release of mtDNA to Promote Apoptosis by Activating cGAS-STING Pathway in Human Colorectal Cancer Cells

• मुख्य लेखकों: Xiaoming Huang (लेखक), Ning Liang (लेखक), Fuming Zhang (लेखक), Wanjun Lin (लेखक), Wenzhe Ma (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2024-05-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Statins are 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductase inhibitors widely used in the treatment of hyperlipidemia. The inhibition of HMG-CoA reductase in the mevalonate pathway leads to the suppression of cell proliferation and induction of apoptosis. The cyclic GMP-AMP synthase (cGAS)...