Natural product manoalide promotes EGFR-TKI sensitivity of lung cancer cells by KRAS-ERK pathway and mitochondrial Ca2+ overload-induced ferroptosis

• Main Authors: Yinyun Ni (Author), Jiaye Liu (Author), Lingyan Zeng (Author), Ying Yang (Author), Lei Liu (Author), Menglin Yao (Author), Li Chai (Author), Lu Zhang (Author), Yi Li (Author), Li Zhang (Author), Weimin Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Manoalide (MA), a proven natural inhibitor of PLA2 has anticancer effects, but its potential application and mechanism as an anticancer drug to promote EGFR-TKI sensitivity in lung cancer cells have not been studied.Methods: KRAS-mutated lung cancer cells and organoids, acquired osimerti...