Detection of minority drug resistant mutations in Malawian HIV-1 subtype C-positive patients initiating and on first-line antiretroviral therapy

• Main Authors: Zhiyong Zhou (Author), Kevin Tang (Author), Guoqing Zhang (Author), Nellie Wadonda-Kabondo (Author), Kundai Moyo (Author), Lori A. Rowe (Author), Joshua R. DeVos (Author), Nick Wagar (Author), Du-Ping Zheng (Author), Hongxiong Guo (Author), John Nkengasong (Author), Mike Frace (Author), Scott Sammons (Author), Chunfu Yang (Author)
• Format: Book
• Published: AOSIS, 2018-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Minority drug resistance mutations (DRMs) that are often missed by Sanger sequencing are clinically significant, as they can cause virologic failure in individuals treated with antiretroviral therapy (ART) drugs. Objective: This study aimed to estimate the prevalence of minor DRMs among...