Differential requirements for Gli2 and Gli3 in the regional specification of the mouse hypothalamus

• Main Authors: Roberta eHaddad-Tóvolli (Author), Fabian ePaul (Author), Yuanfeng eZhang (Author), Xunlei eZhou (Author), Thomas eTheil (Author), Luis ePuelles (Author), Sandra eBlaess (Author), Gonzalo eAlvarez-Bolado (Author)
• Format: Book
• Published: Frontiers Media S.A., 2015-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Secreted protein Sonic hedgehog (Shh) ventralizes the neural tube by modulating the crucial balance between activating and repressing functions (GliA, GliR) of transcription factors Gli2 and Gli3. This balance-the Shh-Gli code-is species- and context-dependent and has been elucidated for the mouse s...