cGAMP-adjuvanted multivalent influenza mRNA vaccines induce broadly protective immunity through cutaneous vaccination in mice

• Autori principali: Wandi Zhu (Autore), Lai Wei (Autore), Chunhong Dong (Autore), Ye Wang (Autore), Joo Kim (Autore), Yao Ma (Autore), Gilbert X. Gonzalez (Autore), Bao-Zhong Wang (Autore)
• Natura: Libro
• Pubblicazione: Elsevier, 2022-12-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Increasing preclinical and clinical results have demonstrated that mRNA vaccines efficiently prevent infectious diseases and are safe in animal models and humans. In this study, we fabricated a multivalent influenza mRNA lipid nanoparticle (LNP) vaccine with mRNAs of hemagglutinins from influenza H1...