Vaccination against the digestive enzyme Cathepsin B using a YS1646 Salmonella enterica Typhimurium vector provides almost complete protection against Schistosoma mansoni challenge in a mouse model.

• Asıl Yazarlar: Adam S Hassan (Yazar), Nicholas H Zelt (Yazar), Dilhan J Perera (Yazar), Momar Ndao (Yazar), Brian J Ward (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Public Library of Science (PLoS), 2019-12-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Schistosoma mansoni threatens hundreds of millions of people in >50 countries. Schistosomulae migrate through the lung and adult worms reside in blood vessels adjacent to the intestinal mucosa. Current candidate vaccines aren't designed to elicit a mucosal response. We have repurposed an att...