Vaccination against the digestive enzyme Cathepsin B using a YS1646 Salmonella enterica Typhimurium vector provides almost complete protection against Schistosoma mansoni challenge in a mouse model.

• Autors principals: Adam S Hassan (Autor), Nicholas H Zelt (Autor), Dilhan J Perera (Autor), Momar Ndao (Autor), Brian J Ward (Autor)
• Format: Llibre
• Publicat: Public Library of Science (PLoS), 2019-12-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Schistosoma mansoni threatens hundreds of millions of people in >50 countries. Schistosomulae migrate through the lung and adult worms reside in blood vessels adjacent to the intestinal mucosa. Current candidate vaccines aren't designed to elicit a mucosal response. We have repurposed an att...