Lipoplexes to Deliver Oligonucleotides in Gram-Positive and Gram-Negative Bacteria: Towards Treatment of Blood Infections

• Main Authors: Sara Pereira (Author), Rita Sobral Santos (Author), Luís Moreira (Author), Nuno Guimarães (Author), Mariana Gomes (Author), Heyang Zhang (Author), Katrien Remaut (Author), Kevin Braeckmans (Author), Stefaan De Smedt (Author), Nuno Filipe Azevedo (Author)
• Format: Book
• Published: MDPI AG, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Bacterial resistance to antibiotics threatens the ability to treat life-threatening bloodstream infections. Oligonucleotides (ONs) composed of nucleic acid mimics (NAMs) able to inhibit essential genes can become an alternative to traditional antibiotics, as long as they are safely transported in hu...