Paraoxonase (PON1 and PON3) polymorphisms: impact on liver expression and atorvastatin-lactone hydrolysis

• Main Authors: Stephan eRiedmaier (Author), Kathrin eKlein (Author), Stefan eWinter (Author), Ute eHofmann (Author), Matthias eSchwab (Author), Ulrich M Zanger (Author)
• Format: Book
• Published: Frontiers Media S.A., 2011-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Atorvastatin δ-lactone, a major, pharmacologically inactive metabolite, has been associated with toxicity. In a previous study we showed that polymorphisms of UGT1A3 influence atorvastatin δ-lactone formation. Here we investigated the reverse reaction, atorvastatin δ-lactone hydrolysis, in a human l...