Paraoxonase (PON1 and PON3) polymorphisms: impact on liver expression and atorvastatin-lactone hydrolysis

• Auteurs principaux: Stephan eRiedmaier (Auteur), Kathrin eKlein (Auteur), Stefan eWinter (Auteur), Ute eHofmann (Auteur), Matthias eSchwab (Auteur), Ulrich M Zanger (Auteur)
• Format: Livre
• Publié: Frontiers Media S.A., 2011-07-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Atorvastatin δ-lactone, a major, pharmacologically inactive metabolite, has been associated with toxicity. In a previous study we showed that polymorphisms of UGT1A3 influence atorvastatin δ-lactone formation. Here we investigated the reverse reaction, atorvastatin δ-lactone hydrolysis, in a human l...