Safety and efficacy of placental mesenchymal stem cell-derived extracellular vesicle in severe COVID-19 patients: Phase I & II Clinical Trials

• Main Authors: Mehdi Jahedi Zargar (Author), Saeed Heidari Keshel (Author), Saeid Kaviani (Author), Mohammad Zahraei (Author), Azadeh Izadyari Aghmiuni (Author), Ali Amir Savadkoohi (Author), Hamidreza Jamaati (Author), Mohammad Samet (Author), Mahsa Soufizomorrod (Author), Mina Soufi Zomorrod (Author), Faeze Sadat Heidari (Author), Mohamad Reza Mirjalili (Author), Payam Tabarsi (Author), Mohammadreza Soroush (Author), Rasoul Aliannejad (Author), Mojtaba Javani (Author), Hosein Shafiii (Author), Mohammad Vasei (Author), Masoud Soleimani (Author)
• Format: Book
• Published: Negah Institute for Scientific Communication, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Most mortality in COVID-19 cases was due to the increased inflammatory cytokines and cytokine storm. As mesenchymal stem cells (MSCs) possess immunomodulatory properties, this study assessed the therapeutic effects of placental MSC-derived extracellular vesicles on the inflammation and...